Abcam, ab225916, Anti-L-Kynurenine Hydrolase antibody

Size: 50µL
Rabbit Polyclonal L-Kynurenine Hydrolase antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Kynureninase aa 1-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Kynureninase aa 1-350. The exact immunogen used to generate this antibody is proprietary information.Q16719

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
L-Kynurenine Hydrolase also known as L-Kynureninase is an enzyme with a mass of approximately 47 kDa. It acts as an important player in the kynurenine pathway by catalyzing the hydrolysis of L-kynurenine into anthranilic acid. This enzymatic activity is important for the degradation of tryptophan. L-Kynureninase is expressed in various tissues including the liver and brain reflecting its importance in systemic metabolic processes.
Biological function summary
L-Kynurenine Hydrolase participates in tryptophan catabolism affecting amino acid metabolism. It operates within the larger enzyme complex involved in the kynurenine pathway which is important for producing metabolites that have neurological and immunological functions. The activity of L-Kynureninase can influence the levels of pathway intermediates which are related to neurotransmitter synthesis and immune responses.
Pathways
This enzyme significantly contributes to the kynurenine pathway which is a major route for tryptophan metabolism. The pathway provides a link to the biosynthesis of nicotinamide adenine dinucleotide (NAD+) an essential coenzyme in cellular respiration. Proteins such as kynurenine 3-monooxygenase and aminocarboxymuconate semialdehyde decarboxylase are closely related to L-Kynureninase in these pathways interacting at different points in the metabolic sequence.
Altered L-Kynurenine Hydrolase activity is associated with conditions like neurodegenerative diseases and certain autoimmune disorders. For instance disruptions in its function can contribute to the development of neurological disorders such as Alzheimer's disease due to imbalanced neuroactive metabolite levels. It also has a connection with proteins like quinolinic acid a neurotoxin that may accumulate when L-Kynureninase activity is impaired linking it to potential damage in neural tissues.