Abcam, ab226010, Anti-CTNNA1 antibody [EP1793Y] - Low endotoxin, Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CTNNA1 antibody. Carrier free. Suitable for IHC-P, IP, WB and reacts with Mouse, Rat, Human samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1793Y,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab226010 is the carrier-free version of
ab51032
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
What does low endotoxin mean?
Our low endotoxin, azide-free formats have low endotoxin level (1 EU/mg, determined by the TAL assay) and are free from azide, to achieve consistent experimental results in functional assays.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTNNA1 also known as alpha-Catenin is an important protein that is involved in cell adhesion. With a molecular weight of about 100 kDa CTNNA1 functions mechanically by linking cadherins which are transmembrane proteins to the actin cytoskeleton in cells. This linkage strengthens cellular junctions and maintains the integrity of tissue architecture. CTNNA1 is widely expressed in epithelial tissues where strong cell-cell adhesion is important for maintaining tissue structure.
Biological function summary
CTNNA1 is important for maintaining cellular integrity and function. It is a part of the adherens junction complex which is critical for the creation of stable cell-cell junctions in tissues. Through the adherens junction it directly associates with E-cadherin and indirectly interacts with the actin cytoskeleton. This structural configuration allows epithelial cells to remain tightly connected facilitating signal transmission between cells for coordinated tissue functioning.
Pathways
CTNNA1 plays a significant role in the Wnt signaling pathway and the regulation of actin dynamics. In the Wnt pathway CTNNA1 is associated with cell fate determination and is known to interact with beta-catenin an important component of this signaling cascade. Additionally by influencing actin cytoskeleton organization CTNNA1 affects cell movement and signal transduction essential for processes like embryogenesis and wound healing.
Disruptions in CTNNA1 function have been linked to cancer and cardiomyopathy. The loss or mutation of CTNNA1 can lead to diminished cell adhesion promoting cancer cell invasion and metastasis often seen in gastric and breast cancers. Moreover its interaction with genes like KIF7 influences cardiomyopathy where structural cardiac tissue changes impair heart function. Understanding CTNNA1's role in these conditions can provide insight for potential therapeutic targets.