Abcam, ab226172, Anti-UGDH antibody

Size: 100µL
Rabbit Polyclonal UGDH antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UDP-glucose 6-dehydrogenase aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UDP-glucose 6-dehydrogenase aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O60701

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab226172 was affinity purified using an epitope specific to UGDH immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UDP-glucose 6-dehydrogenase also known as UGDH is an enzyme with a mass of approximately 53 kDa. It catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid in humans. This enzyme plays an important mechanical role in the biosynthesis of glycosaminoglycans and is expressed in various tissues such as the liver kidneys and lungs. Alternate names for UGDH include UDP-GlcDH and UDPGDH frequently used in scientific literature.
Biological function summary
UDP-glucose 6-dehydrogenase contributes to the conversion processes for nucleotide sugar substrates and it is not reported to be part of a larger enzyme complex. It ensures the availability of UDP-glucuronic acid a necessary precursor for glycosaminoglycans which are components of the extracellular matrix and involved in cellular signaling. This activity supports processes like wound healing and tissue regeneration by maintaining structural integrity and facilitating cell-cell communication in various physiological contexts.
Pathways
UDP-glucose 6-dehydrogenase participates in the hexosamine biosynthetic pathway and the UDP-glucuronate pathway. In the hexosamine biosynthetic pathway it works alongside proteins like glutamine-fructose-6-phosphate transaminase to regulate the production of UDP-GlcNAc important for carbohydrate modifications of proteins and lipids. The UDP-glucuronate pathway involves related enzymes such as hyaluronan synthase which utilizes UDP-glucuronic acid generated by UGDH for synthesizing hyaluronan an important glycosaminoglycan in tissue hydration and lubrication.
Abnormal activity or expression of UDP-glucose 6-dehydrogenase links to cancer and fibrosis. Its role in producing glycosaminoglycans makes it significant in the tumor microenvironment and alterations in UGDH activity may support cancer progression by affecting cell adhesion and migration. In fibrosis overactivity of UGDH can lead to excessive glycosaminoglycan production contributing to tissue scarring. Interactions with proteins like hyaluronan synthase hint at potential therapeutic targets for modifying these extracellular matrix components in disease contexts.