Abcam, ab22639, Anti-PSMC6 antibody [p42-23]

Size: 50µL
Mouse Monoclonal PSMC6 antibody. Suitable for IHC-P, Flow Cyt, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PSMC6.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:p42-23,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PSMC6.P62333

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Partially purified immunoglobulin preparation., Storage buffer-Preservative: 0.065% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PSMC6 protein also known as 26S protease regulatory subunit 8 plays a mechanical role in protein degradation. It functions as a part of the 26S proteasome complex which is involved in the ATP-dependent degradation of ubiquitinated proteins. This protein has a mass of approximately 45 kDa and is widely expressed across various tissues indicating its essential role in cellular processes. PSMC6 contains an ATPase domain which is important for its function within the proteasome.
Biological function summary
PSMC6 assists in the regulation of protein turnover which maintains the balance of protein synthesis and degradation. It is a component of the 26S proteasome which itself forms part of the larger ubiquitin-proteasome system. This system plays a role in removing damaged or unnecessary proteins from the cell maintaining protein homeostasis. The presence of the PSMC6 subunit within the proteasome complex suggests its importance in controlling cellular protein levels and influencing various cellular functions.
Pathways
PSMC6 is implicated in the ubiquitin-proteasome pathway a critical mechanism for protein degradation and cellular regulation. This pathway is central to many cellular processes including cell cycle regulation and signal transduction. PSMC6 interacts with other components of the proteasome like PSMC2 to facilitate the breakdown of ubiquitinated proteins. It is also involved in the Wnt signaling pathway which influences cell proliferation and differentiation.
Dysfunction in PSMC6 has been linked to cancer and neurodegenerative diseases. Its role in the proteasome system suggests that aberrations in protein degradation could lead to the accumulation of damaged proteins associated with these conditions. In cancer for instance altered PSMC6 function may disrupt normal cell cycle regulation. The protein also interacts with other proteasome components like PSMD14 which could further contribute to disease mechanisms when dysregulated.