Abcam, ab22705, Anti-CEACAM5 + CEACAM6 antibody [NCRC16 (AKA 161)]

Size: 50µg
Mouse Monoclonal CEACAM5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:NCRC16 (AKA 161),
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Cross reacts with a similar epitope on NCA.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEACAM5 and CEACAM6 also known as carcinoembryonic antigen-related cell adhesion molecules are glycoproteins involved in cell adhesion processes. CEACAM5 also called CEA has a mass of approximately 180 kDa while CEACAM6 has a mass of around 90 kDa. Both proteins belong to the immunoglobulin superfamily and are anchored to the cell membrane via glycosylphosphatidylinositol. Expression of these proteins occurs mainly in epithelial cells particularly in the gastrointestinal tract respiratory tract and on the surface of granulocytes.
Biological function summary
CEACAM5 and CEACAM6 play important roles in cellular adhesion invasion and signaling. These proteins do not form larger complexes but interact with various cell adhesion molecules to influence cellular behaviors. CEACAM5 involves modulation of immune cell interactions while CEACAM6 aids cell proliferation and differentiation. Their expression levels contribute to modulating cellular communication and stability within tissue structures impacting overall tissue organization.
Pathways
CEACAM5 and CEACAM6 are involved in signaling pathways that regulate cellular movement and immune responses. They participate in pathways related to the MAPK/ERK signaling cascade which controls cell proliferation and survival. These glycoproteins connect with proteins such as integrins enhancing the cellular signaling outcomes and encouraging specific cellular responses. Their interactions within these pathways underline their role in maintaining cellular dynamics.
CEACAM5 and CEACAM6 associate strongly with cancer especially colorectal and lung cancer. Elevated levels of these proteins often indicate tumor progression and metastasis given their involvement in cellular adhesion and signaling. CEACAM5 in particular links with other proteins like MUC-1 in tumor microenvironments influencing cancer cell behaviors. Monitoring these glycoproteins helps in diagnostic and prognostic assessments making them valuable markers in oncological research and practice.