Abcam, ab227727, Anti-PER2 antibody - N-terminal

Size: 100µL
Rabbit Polyclonal PER2 antibody. N-terminal. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PER2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PER2. The exact immunogen used to generate this antibody is proprietary information.O15055

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PER2 protein short for Period Circadian Regulator 2 is an important component of the molecular circadian clock. Alternate names for this protein include PER 2 and per2. This protein has a mass of about 136 kDa and is expressed in various tissues including the brain and liver. PER2 mechanically functions through its role as a transcriptional regulator influencing the expression of genes involved in maintaining circadian rhythm. It forms complexes with other circadian proteins to help regulate these processes.
Biological function summary
The PER2 protein plays an important role in the regulation of genes that control the body's circadian rhythms. It participates in the negative feedback loop of the circadian clock where it is part of a complex with other proteins including CRY1 and CRY2. This complex inhibits its own transcription by repressing the activity of CLOCK and BMAL1 which are core circadian transcription factors. This process results in the oscillations that define circadian rhythms affecting sleep-wake cycles hormone release and various metabolic processes.
Pathways
PER2 is integral to the circadian rhythm pathway and is involved in the regulation of several physiological processes. PER2 along with other proteins like PER1 interacts with the CLOCK-BMAL1 complex which is important in setting and maintaining the circadian rhythms. The interplay of these proteins governs the transcriptional-translational feedback loops that are the foundation of circadian regulation. This pathway is critical for synchronizing the internal clock with the external environment ensuring that biological processes occur at the appropriate times.
PER2 has been linked to sleep disorders such as Familial Advanced Sleep Phase Syndrome (FASPS) and certain mood disorders. Mutations or dysregulation in the PER2 gene may disrupt normal circadian rhythms leading to these conditions. Additionally PER2 has shown connections with cancer where its expression levels can influence tumor progression particularly through interactions with proteins involved in cell cycle regulation. Understanding the precise role of PER2 in these diseases might provide insights for potential therapeutic targets.