Abcam, ab228806, Anti-STK16 antibody

Size: 100µL
Rabbit Polyclonal STK16 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STK16.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STK16. The exact immunogen used to generate this antibody is proprietary information.O75716

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STK16 also known as Serine/threonine-protein kinase 16 or KRCT is a protein kinase that has a mass of approximately 33 kDa. It phosphorylates proteins on serine and threonine residues playing a role in several cellular processes. STK16 is expressed in many body tissues with higher levels detected in the brain liver and spleen. Its widespread expression suggests it has a function in different cellular contexts.
Biological function summary
STK16 influences various processes at the cellular level. It participates in vesicular trafficking and Golgi function ensuring proper sorting and delivery of proteins within cells. Although not typically seen as part of large complexes it interacts with several other proteins to exert its biological roles. The protein’s activity affects cell cycle progression and can influence cellular growth and motility.
Pathways
STK16 integrates into key regulatory networks such as the Golgi-associated vesicle budding pathway and cell signaling pathways. These pathways are important for maintaining cellular organization and communication. STK16’s interactions with proteins like COPII in vesicle trafficking and possibly components of the MAPK signaling cascade highlight its connectivity within cellular pathways and its regulatory potential.
STK16 has been associated with conditions related to cell cycle dysregulation and tumor growth. Dysfunctions in STK16 expression or activity might contribute to the progression of cancers such as breast cancer by impacting cell proliferation and survival. Other kinases like Akt may interact with STK16 or similar pathways influencing disease pathways and offering potential therapeutic intervention points.