Abcam, ab229111, Anti-OXSM antibody

Size: 100µL
Rabbit Polyclonal OXSM antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OXSM.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human OXSM. The exact immunogen used to generate this antibody is proprietary information.Q9NWU1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OXSM also known as 3-oxoacyl-[acyl-carrier-protein] synthase mitochondrial is an important enzyme in the mitochondrial fatty acid synthesis pathway. It participates in the elongation of fatty acids by catalyzing a ketoacyl synthesis reaction. This protein has a molecular mass of approximately 50 kDa. OXSM is mainly expressed in tissues with high metabolic activity such as liver and muscle tissues where it supports the dynamic balance of fatty acid synthesis.
Biological function summary
OXSM plays a part in mitochondrial lipid homeostasis by facilitating the synthesis of longer chain fatty acids. It operates as part of a multiprotein complex that ensures proper substrate channeling and processing. This function is critical for the maintenance and functioning of cellular membranes providing the necessary lipid components. Additionally OXSM contributes to energy production by generating fatty acids that can be converted into acetyl-CoA units within the mitochondria.
Pathways
Several metabolic pathways involve OXSM including the mitochondrial fatty acid synthesis and the broader lipid metabolism pathway. In the mitochondrial fatty acid synthesis pathway OXSM interacts with proteins like Acyl-CoA synthetase family member 1 (ACSF1) to facilitate the progression of fatty acid synthesis. These pathways collectively contribute to energy homeostasis and cellular membrane composition reflecting the interconnectivity between various metabolic functions.
Researchers associate OXSM with rare mitochondrial disorders linked to lipid metabolism. For instance mutations or dysfunctions in OXSM can result in compromised mitochondrial function potentially contributing to neuromuscular disorders. It also connects to carnitine palmitoyltransferase 1A (CPT1A) another key enzyme in fatty acid metabolism which highlights the interconnected nature of mitochondrial metabolic disorders. Understanding OXSM's role in these conditions can lead to better insights for therapeutic strategies.