Abcam, ab229494, Anti-MyT1L antibody

Size: 100µL
Rabbit Polyclonal MYT1L antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYT1L.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYT1L. The exact immunogen used to generate this antibody is proprietary information.Q9UL68

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MyT1L also known as Myelin Transcription Factor 1-like is a transcription factor with a mass of about 125 kDa. It functions mechanically as a DNA-binding protein regulating the expression of specific target genes. You will find MyT1L expressed in the central nervous system including the brain and spinal cord. Its expression also extends to other tissues but is lower compared to neural tissues.
Biological function summary
MyT1L plays a role in neuronal differentiation impacting the development of neural progenitor cells into mature neurons. It does not function as part of a larger protein complex. Instead MyT1L acts independently primarily controlling the transcriptional regulation of genes involved in neuronal development. Its action ensures proper neuronal specification and plasticity critical in forming functional neural networks.
Pathways
MyT1L participates in neurogenesis and central nervous system development pathways. It interacts with proteins like MyT1 and other neurogenic factors orchestrating the intricate processes of neural lineage commitment. MyT1L's involvement in the Notch signaling pathway although less explored may coordinate with these proteins to regulate the fate of neural precursor cells.
MyT1L shows links to neurological conditions such as epilepsy and intellectual disabilities. Changes in MyT1L expression or activity suggest potential disruptions in neural differentiation contributing to these disorders. In epilepsy for instance MyT1L might interact with proteins like MyT1 which could influence the electrical activity balance in neural circuits and lead to the disease pathology.