Abcam, ab229639, Anti-COPB2 antibody

Size: 50µL
Rabbit Polyclonal COPB2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Coatomer subunit beta' aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Coatomer subunit beta' aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P35606

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COPB2 also known as Coatomer Subunit Beta 2 plays a vital role in intracellular protein transport. It is part of the coatomer protein complex which participates in vesicle formation during the transport between the Golgi apparatus and endoplasmic reticulum. This protein has a molecular mass of approximately 102 kDa and is widely expressed in various tissues with significant expression in the liver brain and lungs. Its presence in multiple tissues highlights its broad role in cellular functions.
Biological function summary
COPB2 functions as a component of the larger coatomer complex which is made up of several subunits. This complex facilitates the retrograde transport of proteins from the Golgi back to the endoplasmic reticulum. Through this process COPB2 helps maintain protein homeostasis and ensures that essential proteins are rerouted for proper cellular functioning. Its interaction with other proteins in the coatomer complex supports structural integrity and transport efficiency.
Pathways
COPB2 is integrally involved in the COPI vesicle-mediated transport pathway. This pathway is important for maintaining the secretory pathway's quality control and is interconnected with other pathways such as endocytosis. Related proteins within these pathways include ARF1 which regulates coat recruitment necessary for vesicle formation and other coatomer subunits that collectively influence vesicle trafficking and fusion events.
COPB2 has implications in neurodegenerative diseases and certain cancers. Its function in protein transport becomes critical in conditions where cellular transport mechanisms are disrupted. Abnormal levels or mutations of COPB2 have been associated with Alzheimer’s disease impacting protein aggregation and clearance. Additionally its interactions with proteins such as ARF1 and other coatomer subunits may influence cancer progression by affecting cellular growth and signaling pathways.