Abcam, ab230234, Anti-NAG-2 antibody

Size: 50µL
Rabbit Polyclonal NAG-2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSPAN4 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TSPAN4 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O14817

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NAG-2 also known as Neuronal Apoptosis Inhibitory Protein 2 plays a critical role in inhibiting neuronal apoptosis. This protein weighs approximately 65 kDa and functions in the regulation of cell death mechanisms. NAG-2 is expressed extensively in the central nervous system encompassing regions such as the brain and spinal cord. It performs its mechanical function through interactions with molecules that modulate apoptosis signaling.
Biological function summary
NAG-2 inhibits key pathways that lead to apoptosis helping maintain neuronal survival and function. It often forms part of a larger protein complex involved in cell death pathways. Such a complex allows NAG-2 to influence other proteins that control cellular health and longevity. Its function holds importance in maintaining neural networks and their proper communication.
Pathways
Researchers have identified NAG-2 as playing a role in both the apoptotic signaling pathway and the Bcl-2 family pathway. NAG-2 interacts with other proteins such as Bcl-2 enhancing its anti-apoptotic effects. These interactions place NAG-2 as an important regulator within the cellular survival and apoptosis equilibrium allowing cells to resist unwanted death signals.
NAG-2 influences neurodegenerative conditions including Alzheimer's disease and Parkinson's disease. Dysregulation of NAG-2 function can lead to increased neuronal apoptosis contributing to the progression of these disorders. In Alzheimer's disease its association with proteins such as amyloid-beta indicates a potential therapeutic target for intervention strategies.