Abcam, ab230290, Anti-Integrin alpha 2+beta 1 antibody [16B4] - BSA and Azide free

Size: 100µg
Mouse Monoclonal Integrin alpha 2 antibody. Carrier free. Suitable for Flow Cyt, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:16B4,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab230290 is the carrier-free version of
ab30483
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha 2+beta 1 also known as integrin a2b1 or alpha 2 beta 1 integrin is a heterodimeric cell surface receptor with a mass of approximately 150 kDa. It is expressed on a variety of cells including epithelial and endothelial cells as well as platelets. The primary role of integrin alpha 2+beta 1 involves mediating cell adhesion to collagen a major component of the extracellular matrix. This interaction is critical for maintaining tissue architecture and integrity. The receptor's structure allows it to bind to specific ligands facilitating cell communication and signal transduction across the cell membrane.
Biological function summary
Integrin alpha 2+beta 1 contributes to processes such as cell migration proliferation and differentiation. This integrin functions as part of a larger integrin family complex which includes related integrins like alpha 1 beta 1 and alpha 6 beta 4. These integrins share similarities in structure and function but have distinct binding specificities and tissue distributions. The presence of integrin alpha 2+beta 1 in various tissues indicates its role in tissue-specific cellular activities underlying its contribution to diverse biological functions.
Pathways
Integrin alpha 2+beta 1 is involved in the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are essential for transmitting signals from the extracellular environment to the cell nucleus influencing gene expression and cellular responses. The integrin interacts with proteins such as focal adhesion kinase (FAK) and Src family kinases which are important for initiating downstream signaling events. The interaction of integrin alpha 2+beta 1 within these pathways highlights its role in regulating cellular responses to environmental changes and stresses.
Integrin alpha 2+beta 1 has been linked to cancer metastasis and fibrosis. Its role in promoting cell adhesion and migration is critical in the progression of these diseases. In cancer integrin alpha 2+beta 1 supports tumor cell invasion through the basement membrane by interacting with proteins like matrix metalloproteinases. Fibrosis involves excessive tissue scarring where the integrin contributes to the proliferation of myofibroblasts and deposition of extracellular matrix. Understanding the involvement of integrin alpha 2+beta 1 in these conditions could lead to potential therapeutic targets for intervention.