Abcam, ab230418, Anti-Myh14 antibody

Size: 200µL
Rabbit Polyclonal MYH14 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MYH14 aa 650-700 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MYH14 aa 650-700 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q7Z406

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein Myh14 also known as myosin-14 and non-muscle myosin heavy chain IIC is a member of the myosin superfamily of motor proteins. This protein is approximately 227 kDa in mass and plays an important role in cellular motility by facilitating actin-based transport processes. Myh14 is expressed in various tissues including the heart spleen and cerebellum suggesting its involvement in diverse physiological processes.
Biological function summary
Myh14 functions in the cytoskeleton interacting with actin filaments to contribute to processes like cell shape changes and migration. It acts as a part of the non-muscle myosin IIC complex working in tandem with other cytoskeletal elements to provide structural integrity and tension within cells. This activity supports various cellular mechanisms that require precise mechanical movement and stability.
Pathways
Myh14 plays a role in the Rho GTPase signaling pathway and actin cytoskeleton regulation. These pathways are important for cell adhesion and motility influencing how cells interact and communicate in their environments. Myh14's actions are closely related to proteins such as actin and other myosin family members which collectively maintain cytoskeletal dynamics and cellular responses to external signals.
Myh14 has been linked to sensorineural hearing loss and ischemic stroke. Its relationship with disorders involving the auditory system connects it to proteins like Myh9 another myosin family member associated with similar conditions. In cardiovascular pathology alterations in Myh14 expression may affect cellular responses during tissue damage such as those observed in stroke linking it to physiological processes and potential therapeutic targets.