Abcam, ab230514, Anti-PXK antibody

Size: 200µL
Rabbit Polyclonal PXK antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Pxk aa 150-200 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Pxk aa 150-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8BX57

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PXK also known as Phosphoinositide-binding protein FAM20-kinase or MOYBG Protein Kinase-like is a membrane-associated protein with a molecular mass of approximately 59 kDa. Experts have identified it for its kinase-like properties although it lacks conventional kinase activity. PXK is expressed in various tissues including brain liver and kidney with significant presence in neuronal cells. Its mechanical role involves modulating neuronal signaling and membrane dynamics through interactions with phosphoinositides.
Biological function summary
PXK participates in the regulation of cellular organization and synaptic functions. While not a direct component of signaling complexes it influences processes related to cytoskeletal rearrangement and membrane trafficking. Through its phosphoinositide-binding domains PXK impacts the localization and assembly of proteins involved in synaptic vesicle turnover. As a scaffolding protein it indirectly affects signal transduction pathways by altering the spatial arrangement of interacting proteins.
Pathways
PXK influences the phosphoinositide signaling pathway and the synaptic vesicle cycle. Its interactions with proteins like dynamin and synaptojanin allow researchers to deduce its role in vesicle endocytosis and membrane recycling. PXK indirectly modulates the activity of these proteins impacting the efficiency of synaptic transmission. These pathways underline its role in maintaining synaptic stability and plasticity essential for proper neuronal communication.
Researchers have linked PXK to neurodegenerative diseases and certain immune disorders. Alterations in PXK expression have association with conditions such as Alzheimer’s disease where disrupted synaptic function is an important feature. Furthermore its interaction with immune-related proteins like NF-κB suggests a role in autoimmune processes. These links highlight the importance of PXK in maintaining cellular function and its potential as a therapeutic target in related diseases.