Abcam, ab230629, Anti-SLC22A2 antibody - C-terminal

Size: 50µL
Rabbit Polyclonal SLC22A2 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SLC22A2 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC22A2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O15244

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SLC22A2 protein also known as OCT2 (Organic Cation Transporter 2) is a transmembrane transporter with a molecular mass of approximately 63 kDa. It belongs to the solute carrier family 22 and primarily transports organic cations across cell membranes. SLC22A2 is mainly expressed in the renal tubular epithelial cells in the kidneys but can also be found in the liver and various other tissues at lower levels.
Biological function summary
The SLC22A2 protein facilitates the uptake and excretion of a wide range of endogenous compounds and drugs. This protein mediates the transport of molecules such as dopamine norepinephrine and various pharmaceutical agents. SLC22A2 does not form a complex with other proteins. Its efficient transport function is vital for maintaining the balance and elimination of organic cations within the body.
Pathways
The SLC22A2 protein plays a significant role in the drug metabolism and excretion pathway where it contributes to the renal clearance of medications and endogenous substrates. Additionally it is involved in neurotransmitter release pathways impacting the bioavailability of key neurotransmitters. SLC22A3 a related protein shares functional similarities within these pathways especially in the transport of organic cations.
Alterations or dysfunctions of SLC22A2 can lead to adverse drug reactions and impact conditions such as hypertension and diabetes. Variants or changes in the expression of SLC22A2 can influence drug pharmacokinetics leading to altered drug efficacy and toxicity. The protein SLC22A1 another member of the same solute carrier family shows functional overlap and may contribute to similar pathophysiological conditions when mutated or dysregulated.