Abcam, ab230660, Anti-C1QL3/CTRP13 antibody

Size: 50µL
Rabbit Polyclonal C1QL3/CTRP13 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human C1QL3 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human C1QL3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q5VWW1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C1QL3 also known as CTRP13 is a secreted protein belonging to the C1q/TNF-related protein family. The protein mass is approximately 28 kDa. It mainly expresses in the brain and adipose tissue but has been detected in other tissues too. C1QL3 has a significant role in synaptic function and development through interaction with receptors and neural membranes. Its structural resemblance to other C1q family members hints at potential similar mechanisms of action.
Biological function summary
C1QL3 plays a role in neural signaling and plasticity. It is implicated in the regulation of synapse formation and maintenance. Although it is not part of a larger complex its activity influences the assembly and disassembly of synaptic structures. Such interactions contribute to neural network adjustments essential for brain function. The role of C1QL3 in adipose tissue while less understood suggests a possible link to lipid metabolism.
Pathways
C1QL3 integrates into neural cellular communication pathways. It is linked to the synaptogenesis pathway where it influences synapse maturation. C1QL3 interacts with other proteins including BAIs which are G-protein-coupled receptors critical for transducing signals that guide synaptic connections. The involvement in these pathways underlines the importance of C1QL3 in maintaining neural circuitry balance and efficiency.
C1QL3 associates with neurological conditions such as schizophrenia and obesity. Its interaction with other synaptic proteins points to a possible role in disrupted synapse functioning which is often observed in schizophrenia. In obesity C1QL3 expression in adipose tissue can affect metabolic processes potentially linking it to other mediators like adiponectin that play roles in metabolism regulation. Understanding these associations can offer insights into disease mechanisms and potential therapeutic targets.