Abcam, ab231150, Anti-TRPV3 antibody

Size: 100µg
Rabbit Polyclonal TRPV3 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRPV3 aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TRPV3 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NET8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography, Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TRPV3 protein also known as transient receptor potential cation channel subfamily V member 3 functions as a calcium-permeable channel primarily involved in thermoregulation. With a mass of approximately 91 kDa TRPV3 is activated by warm temperatures and certain chemical compounds including natural oils. It is widely expressed in keratinocytes of the skin as well as in sensory neurons and can be found in other tissues like the brain and hair follicles.
Biological function summary
TRPV3 contributes to temperature sensation and pain perception playing an important role in maintaining skin barrier homeostasis. TRPV3 functions as a homotetramer forming a channel that allows the entry of cations into cells. This channel activity regulates various processes including cell proliferation differentiation and survival especially in the skin cells. Mutations or dysregulation in TRPV3 can result in abnormal skin physiology highlighting its function in epidermal biology.
Pathways
TRPV3 interacts closely with the TRP channel family and integrates into the calcium signaling and MAPK signaling pathways. Within these pathways TRPV3 modulates intracellular calcium levels affecting processes like inflammation and pain signaling. It closely associates with other TRP channels such as TRPV1 which is involved in mediating pain and heat sensation providing a coordinated response to environmental changes.
TRPV3 is linked to conditions such as Olmsted syndrome and atopic dermatitis both characterized by skin abnormalities. In Olmsted syndrome mutations in TRPV3 disrupt normal calcium influx leading to symptoms like palmoplantar keratoderma. Additionally TRPV3 dysregulation might exacerbate atopic dermatitis possibly through interactions with the protein filaggrin which is important for skin barrier function. Understanding TRPV3's role in these contexts can offer insights into potential therapeutic targets for skin-related disorders.