Abcam, ab233260, Anti-TXK/RLK antibody

Size: 100µg
Rabbit Polyclonal TXK/RLK antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Txk aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Txk aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P42682

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TXK also known as RLK is a member of the Tec family of non-receptor tyrosine kinases. It has a molecular mass of approximately 62 kDa. This protein is mainly expressed in the cytoplasm and nucleus of T-cells and natural killer cells. Its structure includes an SH3 domain SH2 domain and a catalytic domain enabling its role as a kinase. TXK contributes to cell signaling by phosphorylating downstream proteins following receptor stimulation.
Biological function summary
The TXK protein functions in the regulation of immune cell activation and differentiation. It interacts with other molecules in the cell to form signaling complexes. In T cells TXK aids in the secretion of cytokines contributing to the immune response. The protein also engages with various cellular pathways to influence transcription factor activity affecting gene expression related to immune function.
Pathways
TXK significantly impacts the T-cell receptor signaling pathway and natural killer cell activation pathway. Its activity links with other proteins such as LCK and FYN which are also involved in the modulation of immune responses. Through these pathways TXK plays a role in regulating cellular responses to external stimuli ultimately affecting immune system function and activity.
TXK has associations with autoimmune diseases and certain types of cancer. In autoimmune conditions such as rheumatoid arthritis abnormal TXK signaling may result in inappropriate immune activation. Furthermore its connections with proteins like FYN highlight TXK's potential involvement in leukemia where dysregulated signaling pathways contribute to uncontrolled cell proliferation. Understanding TXK's roles in these diseases may help in developing targeted therapeutic strategies.