Abcam, ab233480, Anti-REG3G antibody

Size: 100µg
Rabbit Polyclonal REG3G antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human REG3G aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Pig,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human REG3G aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6UW15

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab233480 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
REG3G also known as Regenerating islet-derived protein 3-gamma is a member of the C-type lectin family. It has a molecular weight of about 19 kDa. This protein is expressed mainly in the epithelial cells of the intestine particularly in the ileum and colon. REG3G also shows expression in the pancreas and liver. The primary function of REG3G involves its bactericidal activity where it binds to peptidoglycan in the bacterial cell wall and disrupts it to kill bacteria.
Biological function summary
REG3G plays a role in innate immune responses by maintaining homeostasis in the intestinal mucosa. It is not reported as part of a larger protein complex. REG3G helps modulate the gut microbiota and provides protection against pathogenic bacteria. The ability to control bacterial populations in the gut and prevent invasion highlights the protein’s role in the body's defense mechanisms.
Pathways
REG3G participates in the antimicrobial peptide pathway contributing to mucosal immunity. This pathway plays an important role in the gastrointestinal tract where it prevents infection by pathogens. REG3G is related to other antimicrobial peptides such as REG3A and defensins which collectively enhance the mucosal barrier and protect against microbial invasion.
REG3G is linked to inflammatory bowel disease (IBD) and its expression levels can indicate the inflammatory state of the intestine. Studies have shown that changes in REG3G levels relate to Crohn's disease. Moreover REG3G has connections to diabetes particularly in terms of pancreatic beta-cell stress. It shares functional roles with proteins like REG3B suggesting a broader involvement in tissue regeneration processes.