Abcam, ab233756, Anti-AIM2 antibody [7G12D1]

Size: 100µg
Mouse Monoclonal AIM2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AIM2 aa 1-200.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:7G12D1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AIM2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O14862

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AIM2 also known as Absent in Melanoma 2 is a cytoplasmic sensor with a molecular weight of around 39 kDa. AIM2 plays an important mechanical role in the immune response by detecting cytoplasmic double-stranded DNA (dsDNA) from microbial or host origins. Once activated AIM2 forms an inflammasome complex by recruiting the adaptor protein ASC (Apoptosis-associated Speck-like protein containing a CARD) and then activating caspase-1. AIM2 is expressed in various tissues most prominently within immune cells such as macrophages and dendritic cells.
Biological function summary
AIM2 serves as an important component in the innate immune system by mediating the response to DNA-damaging agents. AIM2's ability to form the inflammasome complex results in the activation of inflammatory responses facilitating the production of pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). This activity plays an important part in the body's defense mechanisms against pathogenic infections and cellular stress.
Pathways
AIM2 integrates into essential immunological signaling namely the inflammasome and innate immune pathways. Within this context AIM2's interaction with proteins like ASC and caspase-1 emphasizes its cross-talk with broader immune system dynamics. Another significant pathway involves the interaction with the cGAS-STING pathway which highlights its contribution to maintaining cellular homeostasis and responding to intracellular DNA.
AIM2 has been implicated in conditions such as autoimmune diseases and cancer. Aberrant AIM2 activity is associated with diseases like systemic lupus erythematosus due to its hyperactive inflammatory responses. Additionally AIM2's connection to proteins like p53 positions it as a player in tumor suppression and highlights its complex role in cancer biology. Understanding AIM2's role offers valuable insights into both therapeutic opportunities and the pathophysiology of these conditions.