Abcam, ab234853, Anti-Inversin antibody

Size: 100µL
Rabbit Polyclonal Inversin antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human INVS aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human INVS aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9Y283

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Inversin also known as INV or INVS is a protein that plays a mechanical role in cellular signaling particularly in the process of cilia assembly and maintenance. It has a molecular weight of approximately 124 kDa. This protein is expressed in various tissues with notable abundance in the kidneys and other ciliated cells. Inversin is important for the function and structure of cells contributing to their ability to sense and respond to environmental cues.
Biological function summary
Inversin acts as an essential modulator of cell-cycle regulation and planar cell polarity. This protein is part of a complex that regulates the Wnt signaling pathway acting as a switch between canonical and non-canonical Wnt pathways. Inversin's role ensures the proper orientation and division of cells which is necessary for correct tissue development and function. In this way Inversin influences cell and organ structure and development.
Pathways
Inversin functions in the Wnt signaling pathway and the Hedgehog signaling pathway. In the Wnt pathway it interacts with Dishevelled proteins modulating pathways to ensure proper signaling for development. In the Hedgehog pathway Inversin plays a role in coordinating signal transduction necessary for embryonic patterning and development. Proper engagement in these pathways ensures the correct relay of signals that influence numerous biological processes.
Inversin has been linked to nephronophthisis and situs inversus. Nephronophthisis a kidney disorder correlates with mutations in the inversin gene which disrupt cilia function. This dysfunction leads to kidney fibrosis and cyst formation. In addition Inversin's connection to situs inversus involves a misalignment in the left-right organization of internal organs highlighting its role in ensuring normal body asymmetry. In these diseases aberrations in proteins such as cystin and inversin contribute to improper cellular and organ function.