Abcam, ab235093, Anti-PNCK antibody

Size: 100µg / 100µL
Rabbit Polyclonal PNCK antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PNCK aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PNCK aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q6P2M8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PNCK also known as Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase is a member of the calcium/calmodulin-dependent protein kinase family. This kinase carries a molecular mass of approximately 39 to 41 kDa. PNCK is mainly expressed in the central nervous system and reproductive tissues including the brain and testis. It participates in phosphorylating various substrate proteins influencing their activity and affecting cellular processes.
Biological function summary
PNCK plays an essential role in modulating cellular responses to calcium signals. It is involved in diverse cellular functions including cell cycle regulation and apoptosis. PNCK acts as a monomer and does not form part of a larger protein complex which gives it distinctive functional properties compared to other kinases involved in similar pathways. The expression and activity of PNCK can vary based on cell type and physiological state.
Pathways
PNCK influences signal transduction mechanisms linked to calcium regulation and cellular communication. It is important in the MAPK/ERK signaling pathway affecting cell proliferation and differentiation. In this context PNCK shows interaction with other proteins like MEK and ERK modulating their activities. Moreover PNCK's role in calcium signaling pathways highlights its potential connections with other calcium-regulated proteins.
PNCK associates significantly with cancer progression and neurodegenerative diseases. Research has indicated its upregulation in certain breast cancer subtypes where it might influence tumor growth and metastasis. PNCK also links with neurodegenerative processes potentially affecting Alzheimer's disease through interactions with proteins such as APP. The connections between PNCK's kinase activity and these diseases highlight its potential as a therapeutic target in related conditions.