Abcam, ab235110, Anti-Sec14l3/TAP2 antibody

Size: 100µL
Rabbit Polyclonal Sec14l3/TAP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9UDX4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sec14l3 also known as TAP2 or Sec14-like protein 3 is a member of the sec14 lipid transfer protein family. It has a molecular mass of approximately 45 kDa. Sec14l3 is expressed in various tissues including the brain suggesting its importance in neural functions. Mechanically Sec14l3 plays a role in lipid binding and transfer assisting in the regulation of phospholipid metabolism important for cellular homeostasis.
Biological function summary
This protein interacts with phosphatidylinositol and phosphatidylcholine contributing to lipid signaling and transport. Sec14l3 is part of a larger complex involved in lipid metabolism influencing various cellular functions by controlling lipid levels within the cell. It modulates membrane trafficking impacting neuron transmission and signaling pathways that direct cellular responses and development.
Pathways
Significant functions of Sec14l3 occur within phosphoinositide signaling and the vesicular transport pathway. It relates to essential proteins in these pathways such as PI3K and small GTPases which govern cell growth survival and intracellular trafficking processes. These interactions affect how cells respond to external signals balancing growth and response to their environment.
Sec14l3 has associations with neurological disorders and cancer. Its interaction with PI3K hints at its role in pathways altered in glioblastomas while its influence on lipid signaling connects it to diseases like Alzheimer's where lipid dysregulation is a factor. Further studies highlight potential links with proteins like tau and amyloid precursor protein in these contexts suggesting pathways for disease progression and potential therapeutic targets.