Abcam, ab235500, RG-7112, MDM2 inhibitor

Size: 5mg
MW 727.8 Da, Purity >98%. Potent, orally bioavailable MDM2 inhibitor that displays antineoplastic activity. Nutlin imidazoline compound. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. Binds MDM2 with K D = 10.7 nM. Blocks the p53- MDM2 interaction with an IC 50 of 18 nM in HTRF assays.
Key facts
CAS number:939981-39-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:727.8 Da,
Molecular formula:C38H48Cl2N4O4S,
PubChem:57406853,
Nature:Synthetic,
Solubility:DMSO 100 mg/mL (138 mM)Ethanol 100 mg/mL (138 mM)Insoluble in water,
Biochemical name:Unii-Q8MI0X869M,
Biological description:Potent, orally bioavailable MDM2 inhibitor that displays antineoplastic activity. Nutlin imidazoline compound. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. Binds MDM2 with KD = 10.7 nM. Blocks the p53- MDM2 interaction with an IC50 of 18 nM in HTRF assays.,
Canonical smiles:CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl,
Isomeric smiles:CCOC1=C(C=CC(=C1)C(C)(C)C)C2=N[C@@]([C@@](N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl,
InChi:InChI=1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1,
InChiKey:QBGKPEROWUKSBK-QPPIDDCLSA-N,
IUPAC Name:[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1919 RG-7112. B1919-5 is the same size as the 5 mg size of ab235500.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark, Store under desiccating conditions