Abcam, ab235540, Anti-GSDMB antibody

Size: 100µL
Rabbit Polyclonal GSDMB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GSDMB aa 50-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GSDMB aa 50-350. The exact immunogen used to generate this antibody is proprietary information.Q8TAX9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GSDMB also known as Gasdermin-B is a protein that plays a significant role in cellular mechanisms. With a molecular weight of approximately 52 kDa GSDMB is encoded by the GSDMB gene. This protein belongs to the gasdermin family and is expressed in various tissues including the stomach esophagus and gastrointestinal tract. Its expression pattern suggests it might have specialized roles in these particular tissues.
Biological function summary
Gasdermin-B is involved in cell death processes particularly in pyroptosis which is a form of programmed cell death. GSDMB forms oligomeric complexes that create pores in the lipid bilayer of cellular membranes. These pores lead to cell swelling and lysis contributing to the inflammatory response. GSDMB also interacts with other gasdermin family proteins indicating a collaborative role in controlling cell death and inflammation.
Pathways
GSDMB is an important component of the pyroptosis pathway and the regulation of immune responses. It interacts with specific members of the caspase family especially Caspase-1 which activates Gasdermin-D in a similar pathway. GSDMB modulates inflammatory signaling by assisting in the release of pro-inflammatory cytokines through its pore-forming activity linking GSDMB to processes that maintain homeostasis and immune defense.
Gasdermin-B has been linked to various inflammatory and autoimmune conditions such as Crohn's disease and ulcerative colitis. Altered expression levels of GSDMB can influence disease severity and progression. Additionally GSDMB interacts with TNF-alpha a cytokine involved in the immune response highlighting its importance in inflammatory disease environments. Exploring GSDMB's role in these conditions can advance therapeutic strategies for treating such disorders.