Abcam, ab235677, Recombinant Human CDR2 protein (His tag)

Size: 100µg
Recombinant Human CDR2 protein (His tag) is a Human Full Length protein, in the 1 to 454 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q01850,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CDR2 also known as Cerebellar Degeneration-Related Protein 2 weighs approximately 52 kDa. It is primarily located in neuronal tissues particularly in the cerebellum. The protein is part of a family of proteins that share similarities including CDR2L which is also found in neuronal tissues. CDR2 plays a mechanical role in regulating neuron function and growth. While it has less common names this protein is consistently referred to in studies involving paraneoplastic neurological disorders.
Biological function summary
CDR2 regulates neuronal signaling and motor control. It interacts with proteins involved in cell cycle control and may form part of a protein complex affecting protein synthesis. Recent research suggests that CDR2 operates in regulating neuronal activity and response to cellular stress. The protein’s expression patterns indicate its significance in maintaining proper cerebellar function and coordination.
Pathways
CDR2 aligns with signaling pathways linked to cerebellar function and neurodegeneration. It is implicated in the mTOR signaling pathway which is important for cell growth and survival alongside proteins like mTOR and RICTOR. The protein is also associated with the beta-catenin signaling pathway suggesting its involvement in processes like cytoskeletal organization and neural cell adhesion.
CDR2 is connected to paraneoplastic cerebellar degeneration and certain types of cancers such as ovarian and breast cancer. These diseases link to the immune response against tumors that mistakenly target neuronal tissue. The protein Yo antibodies are associated with this condition showing a strong connection to CDR2. Their presence in patients indicates an autoimmune aspect where the target’s involvement leads to cerebellar damage and subsequent motor dysfunction.