Abcam, ab235955, Anti-MKLP1 antibody

Size: 100µL
Rabbit Polyclonal MKLP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KIF23 aa 850 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KIF23 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q02241

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MKLP1 also known as mitotic kinesin-like protein 1 is a motor protein with a molecular weight of around 95 kDa. This protein plays an important role in cell division by facilitating the movement of chromosomes and the formation of the spindle apparatus during mitosis. MKLP1 is widely expressed in proliferating cells and tissues especially in those undergoing rapid cell cycles such as embryonic tissues and tumors.
Biological function summary
MKLP1 functions as a component of the centralspindlin complex where it interacts with other proteins to regulate cytoskeletal dynamics. It is critical in the formation and resolution of the central spindle during mitosis ensuring proper separation of cells. By coordinating microtubule bundling and motor activities MKLP1 assists in the maintenance of cell polarity and cell shape changes necessary for mitosis completion.
Pathways
MKLP1 is integral to the mitotic and cell cycle pathways. In particular it is important in the mechanics of the spindle assembly checkpoint which ensures chromosomes are correctly segregated before cell division proceeds. MKLP1 interacts with proteins like Aurora B kinase and ECT2 which regulate the dynamics of cytoskeletal reorganization during these critical phases.
MKLP1 has associations with cancers and neurodevelopmental disorders. In tumors overexpression or mutation of MKLP1 often leads to aneuploidy contributing to tumor progression and metastasis. In the context of neurodevelopmental disorders disruptions in MKLP1 function can relate to conditions such as microcephaly due to its role in cell proliferation. Altered interactions between MKLP1 and proteins like BRCA2 in cancer highlight its relevance in both cell division and stability of the genome.