Abcam, ab236289, Anti-BTN3A1 antibody

Size: 100µL
Rabbit Polyclonal BTN3A1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BTN3A1 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human BTN3A1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.O00481

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BTN3A1 also known as CD277 is an immunoregulatory protein with a mass of approximately 57 kDa. It belongs to the butyrophilin family part of the immunoglobulin superfamily. BTN3A1 is expressed in a variety of tissues including the immune system where it is present on the surface of immune cells such as T cells and natural killer cells. The protein plays a role in the immune cell activation and modulation.
Biological function summary
BTN3A1 functions as a co-stimulatory molecule in immune responses. It forms part of a receptor complex that modulates T cell activation and cytokine production. BTN3A1 is essential for the recognition and response to phosphoantigens which are small phosphorylated metabolites. This function allows BTN3A1 to regulate immune responses effectively and shape the body's defense against infections.
Pathways
BTN3A1 plays a critical role in the regulation of the γΔ T cell activation pathway which is important for immune responses against a variety of pathogens. BTN3A1 interacts with other proteins such as BTN3A2 and B7-H3 facilitating the activation and function of γΔ T cells. These interactions influence the immune system's ability to respond appropriately to infections or malignancies.
BTN3A1 has been implicated in autoimmune diseases and cancer. Alterations in BTN3A1 expression or function can contribute to autoimmune disorders due to dysregulated immune responses. Additionally BTN3A1 is studied in the context of cancer where its interactions with proteins like BTN3A3 may influence tumor immune escape mechanisms. Understanding BTN3A1's role in these conditions provides insights into potential therapeutic targets for managing autoimmune diseases and cancer.