Abcam, ab236379, Anti-CTDSP2 antibody [OTI7F5]

Size: 100µL
Mouse Monoclonal CTDSP2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CTDSP2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI7F5,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CTDSP2.O14595

Product details:
Clone OTI7F5 (formerly 7F5).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTDSP2 also known as CTD Small Phosphatase 2 plays a role in regulating transcription processes by dephosphorylating the C-terminal domain of RNA polymerase II. This protein has a molecular mass around 33 kDa and is expressed in various tissues including the brain and testis. It possesses phosphoserine and phosphothreonine phosphatase activity which is central to its mechanical function in controlling transcriptional elongation and processing.
Biological function summary
CTDSP2 acts by modulating transcription elongation and RNA processing. It forms part of a complex involving other CTD phosphatases ensuring precise regulation of RNA polymerase II activity. This function implies that CTDSP2 participates in managing the transcription cycle and impacts RNA synthesis critical for gene expression and cellular function.
Pathways
CTDSP2 connects to the RNA polymerase II transcription cycle specifically affecting the transcriptional regulation pathway. It functions alongside associated phosphatases like CTDSP1 and CTDSP3 orchestrating the phosphorylation state of RNA polymerase II. These interactions highlight CTDSP2's integration in the fine-tuning of RNA synthesis impacting gene expression fidelity and cellular responses.
Aberrant activity of CTDSP2 associates with neurodegenerative diseases and cancer. Dysregulation in its expression or function often disrupts cellular transcription equilibrium connecting to proteins such as p53 in cancer pathways where it might influence tumor suppressor activities. Similarly CTDSP2 can impact neurodegenerative diseases through pathways involving amyloid precursor proteins showcasing its implication in brain functionality and pathology.