Abcam, ab236385, Anti-FOXN2 antibody [OTI5H8]

Size: 100µL
Mouse Monoclonal FOXN2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FOXN2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI5H8,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human FOXN2.P32314

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXN2 also known as Forkhead Box N2 represents a transcription factor that regulates gene expression. The protein has a mass of approximately 59 kDa and contains a DNA-binding domain known as the Forkhead domain. Researchers have observed FOXN2 expression across various tissues indicating its widespread biological function. Though FOXN2 does not have many popular aliases it plays significant role in cellular processes.
Biological function summary
FOXN2 influences development and cellular differentiation. It acts as a part of the regulation network for gene expression though it does not form a stable complex with other proteins. FOXN2 plays a role in cell cycle regulation where it controls specific target genes necessary for proliferation and development. This control extends to pathways that modulate cellular growth and differentiation.
Pathways
FOXN2 integrates into the broader network of transcriptional regulation in cellular development and differentiation. FOXN2 participates in the Wnt signaling pathway important for controlling cell fate determination. It also interacts with key proteins like β-catenin which links it to cellular growth processes. This connection allows FOXN2 to affect major signaling cascades contributing to normal development.
Abnormalities in FOXN2 function can lead to developmental disorders and cancers. Genetic mutations affecting FOXN2 have connections to certain types of cancer like breast cancer where it may influence tumor formation and progression. Research shows that FOXN2 interacts with proteins such as BRCA1 which further ties its dysregulation to cancer susceptibility. Understanding FOXN2 helps in developing potential therapeutic targets for these diseases.