Abcam, ab236395, Anti-LRRC25/MAPA antibody [OTI1D9]

Size: 100µL
Mouse Monoclonal LRRC25/MAPA antibody. Suitable for IHC-P, WB, Flow Cyt (Intra), ICC/IF and reacts with Human, African green monkey, Recombinant full length protein samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LRRC25.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1D9,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:WB, IHC-P, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human LRRC25.Q8N386

Product details:
Clone OTI1D9 (formerly 1D9).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LRRC25 also known as MAPA is a protein characterized by leucine-rich repeat motifs that facilitate protein-protein interactions. This protein often acts as a receptor within cellular processes. Its molecular mass is approximately 73 kDa. You can find LRRC25 expression in various tissues with a concentration in the immune and epithelial cells reflecting its role in the immune response.
Biological function summary
The protein carries out functions connected to the innate immune system. LRRC25 is involved in modulating cellular responses to external stimuli like pathogens. It is a part of the complex responsible for the immune response working alongside Toll-like receptors. This involvement allows LRRC25 to participate actively in recognizing and responding to microbial infections suggesting its importance for immune activation.
Pathways
LRRC25 plays a role in signaling cascades such as the NF-kB pathway. Its interaction with proteins like MyD88 illustrates its role in signaling pathways leading to inflammation and immune responses. LRRC25 acts as a link between pathogen recognition and downstream transcriptional responses ensuring the proper defense mechanism of the cells.
An altered expression or malfunction of LRRC25 has links to autoimmune diseases and chronic inflammation conditions. For example studies associate LRRC25 with rheumatoid arthritis where it interacts with inflammatory cytokines through the modulation of NF-kB activity. Also researchers observe its association with systemic lupus erythematosus where it may influence the disease's progression by affecting the immune response.