Abcam, ab236399, Anti-MED9 antibody [OTI7F11]

Size: 100µL
Mouse Monoclonal MED9 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MED9.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI7F11,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human MED9.Q9NWA0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MED9 also known as mediator complex subunit 9 is a component of the larger mediator complex involved in transcriptional regulation. It plays a mechanical role in bridging transcriptional regulatory proteins to the RNA polymerase II enzyme. MED9 exhibits a molecular mass of approximately 11 kDa and is expressed widely in human tissue with notably higher levels in heart and skeletal muscle.
Biological function summary
MED9 is an integral part of the mediator complex which is essential for the transcription of nearly all RNA polymerase II-dependent genes. The mediator complex including MED9 facilitates communication between gene-specific regulatory proteins and the polymerase machinery which is important for transcription initiation. MED9 participates in the regulation of multiple genes impacting signal transduction pathways and influencing gene expression.
Pathways
The involvement of MED9 extends to significant biological processes including the MAPK signaling pathway and the Wnt signaling pathway. In these pathways MED9 works alongside other mediator subunits such as MED1 and MED12 to coordinate transcriptional activation. Through these interactions MED9 contributes to the regulation of genes essential for cell growth division and differentiation.
Dysregulation of MED9 has been linked to cancer and cardiac conditions. For instance aberrant MED9 activity may influence oncogenic pathways leading to uncontrolled cell proliferation. In cardiac disorders its interaction with other mediator complex subunits like MED13 and MED14 could result in impaired cardiac function and congenital heart defects. Understanding MED9's role in these contexts can help in designing targeted therapeutic strategies.