Abcam, ab236452, Anti-USP36 antibody

Size: 100µL
Rabbit Polyclonal USP36 antibody. Suitable for Flow Cyt, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP36.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USP36. The exact immunogen used to generate this antibody is proprietary information.Q9P275

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP36 or Ubiquitin Specific Peptidase 36 functions as a deubiquitinating enzyme. It removes ubiquitin moieties from specific protein substrates influencing their stability and degradation. The enzyme weighs approximately 123 kDa. USP36 expresses in various tissues throughout the body with significant levels in the nucleolus. This protein involves in cellular regulation due to its role in controlling ubiquitination which is an important process in protein turnover.
Biological function summary
USP36 plays a role in regulating ribosomal RNA gene transcription and processing. It forms part of complexes that include nucleolar proteins facilitating nucleolar homeostasis. This regulation impacts cell growth and division linking USP36 to fundamental cellular activities such as ribosome biogenesis. By influencing these processes USP36 ensures that cells maintain proper protein synthesis rates necessary for growth and division.
Pathways
Changes in USP36 influence the ubiquitin-proteasome pathway and ribosome biogenesis pathway. USP36 interacts with proteins like FBL (Fibrillarin) and NPM1 (Nucleophosmin) key players in these pathways coordinating ribosomal RNA synthesis and nucleolar architecture. The protein supports the removal of ubiquitin from nucleolar substrates affecting their ability to respond to signaling events related to cell division and stress responses.
Disruption in USP36 activity has links to cancer particularly where nucleolar function is perturbed. It associates with tumorigenesis through interactions with proteins like MYC a well-known oncogene. Additionally aberrations in USP36 function contribute to neurodegenerative disorders through its involvement in protein aggregation drawing connections with ubiquitin-related proteins within cellular maintenance processes.