Abcam, ab236503, Anti-Pea3 antibody [OTI5C11]

Size: 100µL
Mouse Monoclonal Pea3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETV4 aa 1-300.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI5C11,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ETV4 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.P43268

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pea3 also called PEA3 or ETV4 functions as a transcription factor from the ETS family. It has a mass of approximately 55 kDa. This protein regulates gene expression by binding to specific DNA sequences. Pea3 is mainly expressed in the brain lung and liver tissues where it influences the transcription of a range of target genes. It plays an important role in mediating cellular responses to extracellular signals.
Biological function summary
Pea3 influences key processes like cell proliferation differentiation and migration. It often operates within larger protein complexes to execute these roles. Pea3 has been shown to regulate genes involved in development and oncogenic processes by interacting with co-factors in transcriptional complexes. By activating or repressing the transcription of specific genes Pea3 contributes to the dynamic regulation of cellular environments.
Pathways
Several intracellular signaling pathways involve Pea3 in integrating cellular responses to external stimuli. Notably Pea3 plays a role in the MAPK/ERK pathway where it works alongside proteins like ERK and other transcription factors to mediate cell growth and differentiation. Pea3 also participates in the PI3K/AKT pathway influencing cell survival and metabolism. In these pathways Pea3 acts as a bridge linking extracellular signals to transcriptional outputs.
Pea3 connects to cancer progression and metastasis. Overexpression of Pea3 is associated with various cancers including breast and lung cancer where it interacts with proteins like matrix metalloproteinases (MMPs) to promote metastasis. Pea3 also links to neurological disorders by influencing genes involved in brain development and function demonstrating its widespread significance in disease contexts.