Abcam, ab236603, Anti-DHRS3 antibody

Size: 100µL
Rabbit Polyclonal DHRS3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DHRS3 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DHRS3 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O75911

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHRS3 also known as dehydrogenase/reductase member 3 is an enzyme involved in the redox regulation of retinoid metabolism. This enzyme has a molecular mass of approximately 36 kDa. DHRS3 converts retinaldehyde to retinol by reducing retinal in the presence of NADPH pivotal in maintaining retinoid homeostasis. It is expressed in various tissues including the liver and the central nervous system.
Biological function summary
DHRS3 plays a role in the regulation of cellular differentiation development and vision processes by modulating levels of active retinoids. Although not part of a larger complex it is important for controlling the concentration of retinoic acid precursors. The enzyme helps ensure that retinoic acid levels remain within a range that supports normal cell function and organismal development.
Pathways
DHRS3 is integral to the retinol metabolism pathway and indirectly influences the retinoic acid signaling pathway. Through its activity it balances retinol and retinoic acid levels influencing gene expression related to cell proliferation and apoptosis. This enzyme interacts with proteins such as RDH10 within the pathway to modulate retinoid conversion processes critical for cell fate decisions.
Irregularities in DHRS3 function can contribute to the development of metabolic disorders and retinal diseases. Altered expression of DHRS3 has been associated with conditions like obesity as its activity affects lipid metabolism and energy balance. Moreover its interaction with proteins like ALDH1A1 links it to visual impairments and diseases arising from disrupted retinoic acid synthesis.