Abcam, ab236671, Anti-EMP3 antibody

Size: 100µL
Rabbit Polyclonal EMP3 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EMP3 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EMP3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P54852

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EMP3 also known as epithelial membrane protein 3 is a protein with a mass of 25 kDa. This protein belongs to the PMP22/EMP family and is expressed in various tissues including the brain lung and skeletal muscle. EMP3 features a four-transmembrane domain structure and it plays a critical role in cellular communication and signaling. It localizes primarily to the plasma membrane which suggests its involvement in processes requiring membrane interaction.
Biological function summary
EMP3 impacts cell proliferation and differentiation. It participates in the regulation of cell adhesion and may interact with other proteins to influence cellular morphology. Although not part of a larger well-defined complex EMP3's function seems to support the organization and stability of cell-cell junctions. This role implicates it in developmental processes and the maintenance of tissue architecture.
Pathways
EMP3 interacts within cell communication networks. It associates with the MAPK/ERK pathway a major signaling route involved in cell growth and survival. Additionally EMP3's role in the Wnt signaling pathway links it to key regulatory mechanisms in development. These pathways position EMP3 alongside proteins like beta-catenin and ERK highlighting its involvement in signal transmission and potential modulation of gene expression.
EMP3 has connections to certain cancers and neurodevelopmental conditions. Its altered expression has been observed in glioblastoma where it may influence tumor growth and invasiveness. In such contexts EMP3 may work in concert with proteins such as TP53 impacting cell cycle regulation and apoptosis. Additionally research hints at a role in neurodevelopmental disorders implicating its interaction with signaling molecules and contributing to understanding these complex diseases.