Abcam, ab236735, Anti-IFITM2 antibody

Size: 100µL
Rabbit Polyclonal IFITM2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IFITM2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IFITM2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q01629

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The IFITM2 protein also known as Interferon-Induced Transmembrane Protein 2 is a member of the IFITM family which includes IFITM1 and IFITM3. IFITM2 has a molecular mass of approximately 14 kDa. It is found mainly in the plasma membrane and is expressed in various tissues notably immune cells. It functions as part of the cellular response to viral infections acting mechanically to restrict virus entry into the host cell and prevent replication of various viruses.
Biological function summary
The role of IFITM2 extends beyond mechanical blocking as it participates in the immune response by inhibiting the fusion of viral membranes with endosomal membranes. IFITM2 operates together with IFITM1 and IFITM3 forming a complex that boosts its antiviral capacity. The protein contributes to the defense mechanism against a broad range of viral pathogens including influenza and dengue viruses.
Pathways
Research shows that IFITM2 is involved in the interferon signaling pathway which regulates immune response to pathogens. In this pathway IFITM proteins are part of the type I and type II interferon responses enhancing cellular resistance to viral infection. The protein collaborates with others such as STAT1 in maintaining cellular defenses against pathogens.
Several studies have connected IFITM2 to influenza and other viral infections. Altered function or expression of IFITM2 could relate to increased susceptibility to some viral infections or influence the disease progression. The interacts with proteins such as IFITM3 further implicating its involvement in the clinical outcomes of these viral diseases.