Abcam, ab236862, Anti-TMEM68 antibody

Size: 100µL
Rabbit Polyclonal TMEM68 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM68 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM68 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q96MH6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM68 also known as transmembrane protein 68 acts as an enzyme involved in various cellular processes. It has a molecular mass of approximately 26 kDa. This protein is expressed in several tissues with high levels found in adipose tissue skeletal muscle and the liver. Its localization includes the endoplasmic reticulum membrane suggesting a role in membrane-associated functions.
Biological function summary
TMEM68 participates in lipid metabolism facilitating processes related to lipid synthesis and breakdown. Although not directly part of a larger protein complex it interacts closely with molecular structures involved in metabolic pathways. TMEM68's enzymatic activities influence critical cellular components and maintain lipid homeostasis ensuring cells efficiently process and utilize lipid resources.
Pathways
Several critical metabolic routes engage TMEM68 activities. Notably it plays a role in the fatty acid metabolism pathway. TMEM68 interacts with critical enzymes like acetyl-CoA carboxylase and fatty acid synthase aiding in the synthesis and degradation of lipids. These interactions reflect TMEM68's integration into metabolic assemblies that manage energy storage and release within cells.
Altered TMEM68 expression links to metabolic conditions such as obesity and type 2 diabetes. Abnormal activity of this protein affects lipid regulation and leads to dysregulated metabolic states. TMEM68 links to proteins involved in insulin signaling pathways like insulin receptor substrate 1 (IRS1) which further impacts the development and progression of these diseases. Understanding TMEM68's role in such disorders highlights potential therapeutic targets for metabolic interventions.