Abcam, ab236881, Anti-TSPAN5 antibody

Size: 100µL
Rabbit Polyclonal TSPAN5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TSPAN5 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TSPAN5 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.P62079

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TSPAN5 also known as Transmembrane 4 superfamily member 5 is a protein involved in several cellular mechanisms. It belongs to the tetraspanin family characterized by its four transmembrane domains. TSPAN5 has an approximate mass of 27 kilodaltons. The protein is broadly expressed in different tissues including the nervous system and vascular endothelial cells where it plays roles in various cellular processes.
Biological function summary
TSPAN5 interacts with other proteins to influence cell signaling adhesion and migration. It forms part of the tetraspanin web a complex network that organizes membrane proteins into functional units facilitating cell communication and structural organization. This network allows TSPAN5 to affect how cells respond to their environment and organize in multicellular structures.
Pathways
TSPAN5 plays a role in the Wnt signaling pathway which is important for cell development and growth. Its interaction with proteins like β-catenin affects how cells proliferate and differentiate. TSPAN5 is also linked to the Notch signaling pathway mediating cellular communication that influences cell fate decisions. These pathways highlight the significance of TSPAN5 in maintaining normal cellular functions and responses.
TSPAN5 shows associations with certain types of cancer and neurological disorders. In cancers like glioblastoma TSPAN5 interaction with integrins assists in tumor proliferation and metastasis. In neurological disorders it connects with proteins involved in neurotransmission such as synaptic vesicle proteins suggesting a role in conditions like Alzheimer's disease. Understanding these interactions helps target TSPAN5 in therapeutic strategies for these diseases.