Abcam, ab236904, Anti-TM14A antibody

Size: 100µL
Rabbit Polyclonal TM14A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM14A aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM14A aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y6G1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TM14A also known as Transmembrane protein 14A is a protein consisting of 221 amino acids and has a mass of approximately 24.5 kDa. It is mainly located in the plasma membrane where it spans multiple times through the membrane structure. Researchers find TM14A to express prominently in epithelial tissues particularly within the gastrointestinal tract and respiratory system. Given its transmembrane nature it likely plays significant roles in cellular transportation and signaling processes.
Biological function summary
TM14A serves as an important component in cellular transport mechanisms that involve modulation of ion channels. Studies indicate that TM14A is part of a larger protein complex required for these activities. The activity of TM14A influences the movement of ions across the cell membrane affecting cellular homeostasis and communication. It interacts with other membrane proteins facilitating effective signal transduction.
Pathways
TM14A contributes significantly to the Wnt signaling pathway and the MAPK/ERK pathway. Within the Wnt pathway TM14A works alongside proteins like β-catenin to regulate gene expression linked to cell fate determination. In the MAPK/ERK pathway TM14A interacts with proteins such as Ras and Raf facilitating cellular responses to external growth factors. These pathways are essential for controlling various cellular processes like proliferation and differentiation.
Alterations in TM14A expression or function have been associated with colon cancer and cystic fibrosis. In colon cancer TM14A involves dysfunction at a molecular level where it dysregulates the Wnt signaling pathway. This aberration can lead to uncontrolled cellular growth contributing to tumorigenesis. In cystic fibrosis TM14A may have associations with the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein influencing ion transport abnormalities characteristic of the disorder. Understanding TM14A's role in these diseases offers potential therapeutic targets for intervention.