Abcam, ab236911, Anti-PBX1/PRL antibody

Size: 100µL
Rabbit Polyclonal PBX1/PRL antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PBX1 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PBX1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P40424

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PBX1 also known as Pre-B-cell leukemia homeobox 1 is a transcription factor with a molecular mass of approximately 47 kDa. This protein belongs to the TALE family of homeodomain proteins and plays an essential role in gene regulation. PBX1 is widely expressed in many tissues including the pancreas bone marrow and certain regions of the central nervous system. It acts mainly as a DNA-binding protein that regulates the transcription of other genes by forming heterodimers with other proteins.
Biological function summary
PBX1 influences several developmental processes in vertebrates. It frequently partners with HOX proteins to form transcriptional complexes impacting the expression of genes involved in developmental pathways. These complexes assist in cellular differentiation proliferation and morphogenetic patterning. Through these roles PBX1 affects organogenesis maintaining tissue-specific gene expression and ensuring proper development of various tissues.
Pathways
PBX1 plays a part in critical developmental and signaling pathways such as the Wnt signaling pathway and the insulin signaling pathway. Within these pathways PBX1 interacts with proteins like HOXA9 and MEIS1 to regulate gene expression patterns that contribute to cellular function and intercellular communication. These interactions demonstrate the integrative role of PBX1 across single-pathway analysis impacting gene activity and cellular outcomes.
PBX1 links to the pathogenesis of acute lymphoblastic leukemia (ALL) and type 2 diabetes. In leukemia chromosomal translocations involving PBX1 and E2A (TCF3-PBX1 fusion) lead to altered cell cycle regulation and malignant transformation in hematopoietic cells. Furthermore aberrant expression of PBX1 impacts insulin signaling connecting it with the development of insulin resistance in type 2 diabetes. These interactions emphasize PBX1's importance in disease mechanisms revealing potential therapeutic targets for intervention.