Abcam, ab236974, Anti-GLT8D1 antibody

Size: 100µL
Rabbit Polyclonal GLT8D1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GLT8D1 aa 1-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GLT8D1 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.Q68CQ7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLT8D1 also known as Glycosyltransferase 8 domain containing 1 is an enzyme that participates in glycosylation catalyzing the addition of sugars to proteins or lipids. The protein has a mass of approximately 46 kDa. GLT8D1 expression occurs widely including in tissues like the liver and brain. This expression pattern suggests GLT8D1 plays several important roles in various physiological processes.
Biological function summary
GLT8D1 contributes to the modification and stability of proteins. It is not currently recognized as part of a larger complex but interacts within cellular mechanisms to maintain protein function. The enzyme affects cell signaling and communication by modifying surface proteins impacting processes such as development and immune response.
Pathways
GLT8D1 is involved in the protein glycosylation pathway contributing to the modification of glycoproteins. This pathway plays a role in proteostasis affecting quality control of proteins. GLT8D1 might work alongside other glycosyltransferases such as MGATs which also participate in protein modification although specific direct interactions might not be well-characterized.
GLT8D1 mutations or altered activity have been associated with certain neurodegenerative conditions such as spinocerebellar ataxia. In these diseases disruptions in glycosylation processes might impact overall neuronal function and stability. GLT8D1 might also engage indirectly with proteins like ataxin which participate in related pathways affecting neuronal health and disease progression.