Abcam, ab237054, Anti-MCART1 antibody

Size: 100µL
Rabbit Polyclonal MCART1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A51 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC25A51 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9H1U9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MCART1 also known as Metabolic Cart1 is a mitochondrial protein involved in maintaining cellular energy homeostasis. It has a molecular mass of approximately 35 kDa. This protein is mainly expressed in tissues with high metabolic activity such as the heart liver and skeletal muscle indicating its importance in tissues requiring robust energy metabolism. MCART1 facilitates interactions within mitochondria contributing to their complex bioenergetic functions.
Biological function summary
MCART1 plays a major role in the regulation of mitochondrial oxidative phosphorylation. It functions in concert with respiratory complexes to ensure efficient electron transport and ATP production. MCART1 integrates into mitochondrial morphology and dynamics acting as a part of a larger protein complex. This suggests its critical participation in maintaining mitochondrial structural and functional integrity.
Pathways
MCART1 influences pathways related to energy metabolism and mitochondrial dynamics. It participates in the oxidative phosphorylation pathway interacting with components of the electron transport chain. Additionally MCART1 exhibits relationships with proteins such as MICOS complex members highlighting its involvement in mitochondrial inner membrane organization and function.
MCART1 shows associations with metabolic disorders and mitochondrial diseases. Abnormal MCART1 function can lead to mitochondrial dysfunction contributing to disorders like Leigh syndrome. Furthermore MCART1's interaction with various electron transport chain proteins links it to conditions involving oxidative stress and cellular energy deficits.