Abcam, ab237235, Alexa Fluor® 647 Anti-HuD + HuC antibody [EPR19098]

Size: 100µL
Anti-HuD + HuC antibody [EPR19098] - Alexa Fluor® 647 conjugated (ab237235) is a rabbit recombinant monoclonal antibody detecting HuC in IHC-P . Suitable for Human, Mouse . - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19098,
Isotype:IgG,
Conjugation:Alexa Fluor® 647,
Excitation/Emission:Ex: 650nm, Em: 665nm,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody shows very weak cross reactivity to HuB in WB test. Please contact our Scientific support team for more information.

Product details:
What is this antibody validated in?
Alexa Fluor® 647 Anti-HuD + HuC antibody [EPR19098] (ab237235) is a rabbit recombinant monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human, Mouse samples.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Related products
Antibody clone EPR19098 is also available pre-conjugated to a variety of labels for your convenience – Anti-HuC Alexa Fluor® 647 HuD + [EPR19098] (ab237235).
Other related products
We have a range of other formats of antibody clone [EPR19098] also available for your convenience:
ab200342
, Alexa Fluor® 647 -
ab209609
, Carrier free -
ab242410
, APC -
ab310841
, PE -
ab310913
, Alexa Fluor® 488 -
ab310967
, Alexa Fluor® 594 -
ab311680
, Alexa Fluor® 568 -
ab312955
, Alexa Fluor® 555 -
ab313164
, Alexa Fluor® 750 -
ab321346
, Carrier free -
ab232416
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle|Stable for 12 months at -20°C|Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HuD and HuC proteins also known as neuronal ELAV-like RNA binding proteins play critical roles in neuronal development and function. These proteins weigh approximately 37 kDa and are specifically expressed in neurons. They are part of the family of ELAV (Embryonic Lethal Abnormal Vision) proteins with HuD sometimes referred to as C HuD. HuD and HuC are involved in RNA stabilization processes by binding to AU-rich elements in the 3' untranslated regions (3' UTR) of mRNA which influence the regulation of mRNA turnover stability and translation.
Biological function summary
HuD and HuC proteins are integral to the regulation of gene expression during neuronal differentiation. They participate in RNA processing machinery and can form complexes with other RNA-binding proteins affecting the neuronal mRNA transcriptome. These interactions facilitate the stabilization and localization of mRNAs essential for synaptic plasticity and neuron functionality. Their presence highlights the post-transcriptional regulation mechanisms vital for nervous system development and function.
Pathways
HuD and HuC proteins are essential players in neuron-specific mRNA processing pathways. They interact closely with molecular pathways involved in learning and memory particularly those involving the MAPK/ERK pathway. They frequently co-regulate mRNA with other proteins like HuR a ubiquitous ELAV protein. These interactions assist in the modulation of gene expression profiles necessary for proper neuronal signaling and plasticity.
HuD and HuC proteins are linked with conditions such as neurological cancer and neurodegenerative disorders. Their deregulation has been associated with neuroblastoma where aberrant expression influences tumor proliferation. Additionally alterations in HuD and HuC protein function have connections with Alzheimer's disease wherein their interactions with tau protein impact disease progression. Understanding these associations provides insights into potential therapeutic targets and interventions for such conditions.