Abcam, ab23738, Anti-FOXA1 + FOXA2 antibody

Size: 100µg
Anti-FOXA1 + FOXA2 antibody (ab23738) is a rabbit polyclonal antibody detecting FOXA1 + FOXA2 in Western Blot . Suitable for Human . - Over 160 publications - Trusted since 2006
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Please note ab23738 has slight cross-reactivity with FOXA3

Product details:
What is this antibody validated in?
Anti-FOXA1 + FOXA2 antibody (ab23738) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB) in Human samples.
What is the molecular weight of FOXA1?
Anti-FOXA1 + FOXA2 antibody (ab23738) detects a band for FOXA1 (UniProt: P55317) at a molecular weight of 49kDa.
Trusted by the scientific community
Anti-FOXA1 + FOXA2 antibody (ab23738) was first used in a scientific publication in 2006 and has been cited over 160 times in peer-reviewed journals.
Reviewed by scientists
Anti-FOXA1+ FOXA2 antibody (ab23738) has over 10 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXA1 also known as Forkhead Box A1 is a transcription factor with a molecular weight of about 49 kDa. It plays a role by binding to specific DNA sequences influencing the expression of genes involved in various cellular processes. This protein is expressed in tissues like liver lungs and prostate. Researchers also refer to FOXA1 as HNF-3α emphasizing its importance in transcription regulation.
Biological function summary
FOXA1 influences the transcriptional control of genes essential for organ development and metabolic regulation. It acts as a pioneer factor opening chromatin structure to enable access for other transcription factors. FOXA1 integrates into complexes that involve histone modification affecting the chromatin state and transcription of target genes. This function is necessary for the proper differentiation and function of several tissues.
Pathways
FOXA1 participates significantly in the androgen receptor signaling pathway and the estrogen receptor signaling pathway. It interacts closely with androgen receptor facilitating the expression of genes that influence cell growth and proliferation. The involvement of FOXA1 in these pathways highlights its critical role in pathways that regulate hormone-responsive cancers and metabolic processes.
FOXA1 shows a strong association with cancers such as prostate cancer and breast cancer. FOXA1's interaction with the androgen receptor links it to prostate cancer progression while its involvement with the estrogen receptor correlates with breast cancer development. Aberrations in its expression or function can disrupt these pathways emphasizing the importance of FOXA1 in cancer biology and its potential as a therapeutic target.