Abcam, ab238113, Anti-Dscam antibody

Size: 100µL
Rabbit Polyclonal DSCAM antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Down syndrome cell adhesion molecule aa 1700-1900.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Down syndrome cell adhesion molecule aa 1700-1900. The exact immunogen used to generate this antibody is proprietary information.O60469

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Dscam known as Down Syndrome Cell Adhesion Molecule is a protein with a mass of around 230 kDa. It functions as a cell adhesion molecule and is involved in axon guidance. Dscam is expressed in various tissues with high levels in the nervous system particularly during developmental stages. The protein plays a role in neural development by ensuring proper neuronal connections.
Biological function summary
Dscam contributes to neuronal differentiation and synaptic targeting. It belongs to the immunoglobulin superfamily and is involved in forming non-covalent complexes with other cell adhesion molecules. The protein facilitates homophilic binding which regulates axonal and dendritic branching. This process ensures neural circuits form correctly impacting brain development and function.
Pathways
Dscam participates in the neural development pathway which includes interactions with the Robo receptor affecting axonal migration and guidance. The protein also links to the slit-Robo pathway playing a substantial role in neural patterning. These interactions ensure the precise wiring required for functional neural networks influencing how neural signals propagate.
Dscam's dysregulation connects to neurological conditions like Down syndrome and autism spectrum disorders. It interacts with proteins involved in these disorders like the ROBO proteins which mediate axon guidance. Accumulating evidence suggests that altered Dscam expression impairs neuronal connectivity contributing to the pathophysiology of these conditions.