Abcam, ab238140, Anti-Tetraspanin-33 antibody [EPR23121-146]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Tetraspanin-33 antibody. Suitable for Flow Cyt, Dot and reacts with Human, Recombinant fragment - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23121-146,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tetraspanin-33 also known as TSPAN33 or TSPN33 is a protein belonging to the tetraspanin family. It plays a role in organizing other proteins into functional complexes on the cell surface. Tetraspanin-33 weighs approximately 34 kDa and is mainly expressed in hematopoietic tissues which include the bone marrow and lymphoid organs. It is a transmembrane protein with four domains that spans the lipid bilayer influencing cell signaling by clustering with integrins and other membrane proteins.
Biological function summary
The organization of proteins into complexes forms an important function of Tetraspanin-33 in the immune system. It regulates cell adhesion migration and signaling impacting various types of immune responses. Tetraspanin-33 interacts with integrins forming tetraspanin-enriched microdomains. Such interactions stabilize the functional arrangements of signaling molecules ensuring precise communication and activation in immune cells.
Pathways
Tetraspanin-33 has influential roles in integrin-mediated signaling and immune response pathways. It modulates beta-1 integrin activity and works alongside proteins such as CD9 and CD81 which are also tetraspanins involved in the orchestration of cell adhesion and motility. The signaling modulated by Tetraspanin-33 plays key roles in mediating the cell-cell interactions needed for effective immune function providing a scaffold necessary for the activation and regulation of signaling cascades.
Dysfunctions involving Tetraspanin-33 appear in immune system disorders and certain types of cancer. Aberrant expression or mutations can relate to conditions such as leukemia where Tetraspanin-33 interacts with proteins like CD53 another tetraspanin involved in immune cell signaling. Additionally alterations in Tetraspanin-33 function might contribute to autoimmune disorders highlighting its importance in maintaining immune system balance and responding to pathogens properly.