Abcam, ab238166, Anti-CD94 antibody [EPR21003] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CD94 antibody. Carrier free. Suitable for IHC-P, WB, IP and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21003,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab238166 is the carrier-free version of
ab235441
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD94 also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1) plays a significant mechanical role in the immune system. This protein forms part of a receptor family involved in natural killer (NK) cell function. CD94 typically assembles on the cell surface as a heterodimer often pairing with NKG2 proteins. Weighing approximately 30 kDa CD94 mainly exhibits expression on NK cells and a subset of T cells where it contributes to immune regulation.
Biological function summary
CD94 is essential in recognizing and binding to non-classical MHC class I molecules when it pairs with NKG2 molecules such as NKG2A or NKG2C. This dimer forms a complex receptor which plays an important role in modulating NK cell activity. Through this receptor complex CD94 influences the immune response by either inhibiting or activating NK cells depending on its NKG2 partner. This regulation helps maintain a balanced immune response preventing excessive activation and autoimmunity.
Pathways
CD94 interacts with the signaling pathways related to the immune response. In particular it is involved in the natural killer cell lectin-like receptor signaling pathway. This pathway manages the activation and inhibition of NK cells integrating signals received through various receptors including CD94/NKG2 dimers. Associated proteins like DAP12 may amplify these signals which ultimately influence cytotoxic activities and cytokine production.
CD94 has notable connections with conditions such as cancer and viral infections. For example certain tumors manipulate CD94 expression on NK cells to evade immune surveillance. Additionally alterations in CD94 and its partner molecules like NKG2A have been observed in viral infections possibly affecting how the immune system responds. Understanding CD94's relationship with these diseases can offer insights into potential therapeutic strategies targeting immune regulation.