Abcam, ab238487, Anti-ATP2C1 antibody

Size: 100µL
Rabbit Polyclonal ATP2C1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ATP2C1 aa 450-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ATP2C1 aa 450-650. The exact immunogen used to generate this antibody is proprietary information.P98194

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP2C1 also known as Secretory Pathway Calcium ATPase 1 (SPCA1) is an essential calcium pump. It has a molecular mass of approximately 115 kDa. ATP2C1 is located on the Golgi membrane and participates in maintaining calcium and manganese ion homeostasis by transporting these ions from the cytosol into the Golgi apparatus. It shows expression in various tissues with high levels found in epithelial cells.
Biological function summary
The efficient functioning of ATP2C1 regulates calcium ion concentration within the Golgi impacting protein sorting and processing. This protein contributes to cellular signaling and is a part of a broader family of P-type ATPases. Although ATP2C1 does not form part of a complex its activity indirectly influences the function of other calcium-binding proteins through its ion transport role.
Pathways
ATP2C1 participates in key calcium homeostasis pathways ensuring cellular functions related to calcium-dependent processes. It plays a role in the intracellular signaling pathway that involves calcium-regulated gene expression. ATP2C1 is functionally linked to proteins such as STIM1 and Orai1 which are critical in the process of calcium reabsorption and signaling.
Dysfunctional ATP2C1 activity associates with Hailey-Hailey disease a genetic disorder causing recurring blisters and erosions of the skin. Mutations in the ATP2C1 gene result in impaired calcium ion transport contributing to the skin lesions. This condition shows links to the protein desmoglein-1 involved in cell adhesion suggesting disrupted adhesion due to altered calcium ion homeostasis.