Abcam, ab238562, Anti-Eosinophil derived neurotoxin antibody

Size: 100µL
Rabbit Polyclonal Eosinophil derived neurotoxin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RNASE2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RNASE2.P10153

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Eosinophil derived neurotoxin also known as EDN or Ribosomal protein S14 is a multifunctional protein with several biological roles. EDN weighs approximately 18 kDa and is predominantly found in eosinophils a type of white blood cell involved in immune response. Beyond eosinophils this protein can exist in tissues where inflammation occurs. EDN performs various mechanical roles including ribonuclease activity which allows it to degrade RNA substrates efficiently. This ribonuclease property contributes to its wide range of biological functions.
Biological function summary
The eosinophil derived neurotoxin performs significant immune modulation roles. EDN modulates immune activity by acting as an attractant for dendritic cells and T-cells all important players in the immune system. Although not part of a larger protein complex EDN interacts with other immune molecules to propagate inflammatory reactions. Its involvement in antiviral activity also indicates EDN possesses the ability to participate in defense against viral infections enhancing immune responses in tissues where viral invasion occurs.
Pathways
Eosinophil derived neurotoxin plays essential roles in immune signaling and inflammatory pathways. In the immune signaling pathway EDN interacts with key proteins such as IL-5 and eotaxin which guide the recruitment and activation of eosinophils. Inflammatory pathways involving EDN include the promotion of inflammation through cytokine release and cell infiltration. Furthermore EDN is related to ribonuclease proteins through its ribonucleolytic activities linking it to enzymatic degradation pathways which impact RNA processing during immune responses.
Eosinophil derived neurotoxin is associated with conditions like asthma and allergic responses where it amplifies inflammation and tissue damage. In asthma EDN interacts with major basic protein and eotaxin compounds critical in exacerbating bronchial inflammation and hyperresponsiveness. In allergic conditions EDN contributes to the immune system's excessive response to allergens often resulting in tissue damage due to prolonged inflammation. These roles underline the importance of EDN as a target for potential therapeutic intervention in allergy and asthma management.